Select a tab to view spatial gene expression, cell type locations, or cell-cell interactions
Gene expression
Cell locations
Cell interactions
Steady state
Malaria
Step 1: Search for your favourite gene in the searchbars!
Step 2: Select other genes in the second and third searchbars.
Step 3: Show or hide genes by clicking on the legend.
Locations with expression of Gene 1, Gene 2, or Gene 3 appear in blue, red, and yellow, respectively.
Gene 1
Gene 2
Gene 3
Step 1: Search for your favourite gene in the searchbars!
Step 2: Select other genes in the second and third searchbars.
Step 3: Show or hide genes by clicking on the legend.
Locations with expression of Gene 1, Gene 2, or Gene 3 appear in blue, red, and yellow, respectively.
Gene 1
Gene 2
Gene 3
Steady state
Malaria
Step 1: Select cell types from the drop down menus below to see their inferred locations, then use the sliders to change their colours or dot sizes.
Step 2: Light up different microanatomical compartments using the Microarchitectural Feature option.
Step 3: Navigate using the toolbar at the top right.
Microarchitectural feature
B cell zone
Marginal zone
Erythrocytes
T cell zone
Red pulp
Plasmablasts
None
Channel 1
ARC
B ASC
B B1
B follicular
B MZ
CD4+ iNKT
CD4+ T naive
CD4+ Treg
CD8+ T naive
cDC1
cDC2
Erythrocyte
FDC
FRC
Granulocyte
Macrophage
Monocyte
NK cell
pDC
RP FB
Blank
Channel 2
ARC
B ASC
B B1
B follicular
B MZ
CD4+ iNKT
CD4+ T naive
CD4+ Treg
CD8+ T naive
cDC1
cDC2
Erythrocyte
FDC
FRC
Granulocyte
Macrophage
Monocyte
NK cell
pDC
RP FB
Blank
Channel 3
ARC
B ASC
B B1
B follicular
B MZ
CD4+ iNKT
CD4+ T naive
CD4+ Treg
CD8+ T naive
cDC1
cDC2
Erythrocyte
FDC
FRC
Granulocyte
Macrophage
Monocyte
NK cell
pDC
RP FB
Blank
Channel 4
ARC
B ASC
B B1
B follicular
B MZ
CD4+ iNKT
CD4+ T naive
CD4+ Treg
CD8+ T naive
cDC1
cDC2
Erythrocyte
FDC
FRC
Granulocyte
Macrophage
Monocyte
NK cell
pDC
RP FB
Blank
Point size
Step 1: Select cell types from the drop down menus below to see their inferred locations, then use the sliders to change their colours or dot sizes.
Step 2: Light up different microanatomical compartments using the Microarchitectural Feature option.
Step 3: Navigate using the toolbar at the top right.
Microarchitectural feature
Marginal zone
Red pulp
Erythrocytes
Outer follicle
Inner follicle
Plasmablasts
None
Channel 1
ARC
B activated
B ASC
B bystander
CD4+ iNKT
CD4+ T bystander
CD4+ T proliferating
CD4+ Tcmp
CD4+ Tfh
CD4+ Th1
CD4+ Treg
CD8+ T bystander
CD8+ T effector
cDC1
cDC2
Erythrocyte
FDC
FRC
Granulocyte
Macrophage
Monocyte
NK cell
pDC
RP FB
Blank
Channel 2
ARC
B activated
B ASC
B bystander
CD4+ iNKT
CD4+ T bystander
CD4+ T proliferating
CD4+ Tcmp
CD4+ Tfh
CD4+ Th1
CD4+ Treg
CD8+ T bystander
CD8+ T effector
cDC1
cDC2
Erythrocyte
FDC
FRC
Granulocyte
Macrophage
Monocyte
NK cell
pDC
RP FB
Blank
Channel 3
ARC
B activated
B ASC
B bystander
CD4+ iNKT
CD4+ T bystander
CD4+ T proliferating
CD4+ Tcmp
CD4+ Tfh
CD4+ Th1
CD4+ Treg
CD8+ T bystander
CD8+ T effector
cDC1
cDC2
Erythrocyte
FDC
FRC
Granulocyte
Macrophage
Monocyte
NK cell
pDC
RP FB
Blank
Channel 4
ARC
B activated
B ASC
B bystander
CD4+ iNKT
CD4+ T bystander
CD4+ T proliferating
CD4+ Tcmp
CD4+ Tfh
CD4+ Th1
CD4+ Treg
CD8+ T bystander
CD8+ T effector
cDC1
cDC2
Erythrocyte
FDC
FRC
Granulocyte
Macrophage
Monocyte
NK cell
pDC
RP FB
Blank
Point size
Steady state
Malaria
Click a box in the heatmap of colocalisations to see inferred ligand-receptor interactions between two cell types.
x axis entries are in the format:
ligand -> receptor
where the ligand is expressed by the left cell type and the receptor is expressed by the right cell type.
y axis indicates the degree of confidence in an interaction inferred by the CellChat algorithm.
Ligand-receptor interaction inference is based on mRNA expression only and does not account for cell positioning.
Click a box in the heatmap of colocalisations to see inferred ligand-receptor interactions between two cell types.
x axis entries are in the format:
ligand -> receptor
where the ligand is expressed by the left cell type and the receptor is expressed by the right cell type.
y axis indicates the degree of confidence in an interaction inferred by the CellChat algorithm.
Ligand-receptor interaction inference is based on mRNA expression only and does not account for cell positioning.